Gene‐diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study

Gene‐diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study

Blog Article

Abstract Introduction Type 2 diabetes (T2D) is multifactorial involving lifestyle, environmental and genetic risk factors.This study aims Madeleine Pans/Molds to investigate the impact of genetic interactions with alcohol and diet quality on glycated haemoglobin A1c (HbA1c) independent of obesity, in a British population.Methods Cross‐sectional study of 14 089 white British participants from Airwave Health Monitoring Study and a subsample of 3733 participants with dietary data.A T2D genetic risk score (GRS) was constructed, and its interactions with diet on HbA1c were assessed.

Results GRS was associated with a higher HbA1c% (β = 0.03, P < 0.0001) and a higher risk of prediabetes (OR = 1.09, P < 0.

0001) and T2D (OR = 1.14, P = 0.006).The genetic effect on HbA1c% was significantly higher in obese participants (β = 1.

88, Pinteraction = 0.03).A high intake of wholegrain attenuated the effect on Card Sleeves HbA1c% in high‐risk individuals Pinteraction = 0.04.

Conclusion The genetic effect on HbA1c was almost doubled in obese individuals, compared with those with a healthy weight, and independent of weight, there was a modest offset on HbA1c in high‐genetic‐risk individuals consuming a diet high in wholegrain.This supports the importance of a healthy diet high in wholegrains and along with maintaining a healthy weight in controlling HbA1c among high‐genetic‐risk groups.